Create gene sets and run GSEA for DBA by genotype from O’Brien et al. and Ludwig et al.

Import libraries

Identify most variable genes between groups in the two reference datasets. Create erythroid signature gene sets.

RMA-normalized, DBA vs. Control from Ludwig et al.

RMA-normalized, DBA (RP/I) vs. Control from O’Brien et al.

RMA-normalized, DBA (GATA1) vs. Control from O’Brien et al.

Synthetic norm of RMA-normalized, DBA (RP/I) vs. Control from O’Brien et al.

Synethic norm of RMA-normalized, DBA (GATA1) vs. Control from O’Brien et al.

Synthetic norm-normalization of RMA-normalized, DBA (RP/I) vs. Control from O’Brien et al.

Synethic norm-normalization of RMA-normalized, DBA (GATA1) vs. Control from O’Brien et al.

RMA-normalized, GSE22552 reference set

RMA-normalized, GSE24759 reference set